"This study demonstrates the potential of mining 'real-world' data to identify therapy modifiers for improving patient outcomes. Lower amounts of dietary vitamin A correlated with increased risk and severity of AAP. Concomitant use of vitamin A correlated with a 60% reduction in the risk of AAP.
They found that only 1.4% of patients treated with asparaginase developed pancreatitis when they were also taking vitamin A in contrast to 3.4% of patients who did not. Ultimately, the team established two sets of human "real-world" experiences. The research team also studied data from mice experiments and compared plasma samples from people with ALL who developed pancreatitis and those who did not.
#Open risk engine software#
This number crunching and predictive analytics work included use of the AERSMine software developed at Cincinnati Children's by Mayur Sarangdhar, PhD, MRes, and colleagues. Federal Drug Administration Adverse Events Reporting System. The team found more supporting evidence by "mining" millions of of electronic health records from the TriNetX database and the U.S. Jegga and colleagues developed predictive analytics using over 100 million data points encompassing gene expression data, small-molecule data, and electronic health records to understand more of the mechanisms driving asparaginase-associated pancreatitis (AAP) and identify potential interventions to prevent or mitigate AAP.įirst, they analyzed massive amounts of gene expression data to reveal that gene activity associated with asparaginase or pancreatitis might be reversed by retinoids (vitamin A and its analogs). For a third of these people, the symptoms can be severe. However, an estimated 2% to 10% of asparaginase users develop inflammation of the pancreas in reaction to asparaginase treatment. The medication, often used in combination with other chemotherapies, is given via injection into a vein, muscle, or under the skin. For people with ALL, treatment with the enzyme asparaginase helps starve cancer cells by reducing the amount of asparagine circulating in the blood, which the cancer cells need but cannot make themselves. The research team was led by Sohail Husain, MD, chief of Pediatric Gastroenterology, Hepatology, and Nutrition at Stanford University and Anil Goud Jegga, DVM, MRes, a computational biologist at Cincinnati Children's Hospital Medical Center. According to a study, a diet high in vitamin A or its analogues might assist adolescents and young adults with acute lymphoblastic leukaemia (ALL) in lowering their risk of painful pancreatic inflammation during chemotherapy.ĭetails about this potential dietary solution to prevent a potentially life-threatening adverse event were published March 15, 2023, in Science Translational Medicine.
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